Anti-Lnk/SH2B adapter protein 3 Antibody

产品说明

一般描述

Lnk is an SH2B3 multidomain adaptor protein that is primarily expressed in lymphocytes. It contains the characteristic pleckstrin homology (PH); src homology 2 (SH2); dimerization; and proline-rich domains. Lnk functions as a negative regulator of B cell proliferative processes via interaction with Jak2 and Mpl proteins, and inhibition of the PI3/Akt/STAT5 signaling pathway. Previous studies have implicated Lnk in celiac disease type 13.

特异性

This antibody recognizes Lnk/SH2B adapter protein 3 at the C-terminus.
Other homologies: Rat (78% sequence homology) and Mouse (72% sequence homology).

免疫原

Epitope: C-terminus
KLH-conjugated linear peptide corresponding to the C-terminus of human Lnk/SH2B adapter protein 3.

应用

Research Category
Cell Structure
Detect the Lnk/SH2B adapter protein 3 protein using this Anti-Lnk/SH2B adapter protein 3 validated for use in WB.
Research Sub Category
Adhesion (CAMs)

质量

Evaluated by Western Blot in HepG2 cell lysate.

Western Blot Analysis: 0.5 µg/mL of this antibody detected Lnk/SH2B adapter protein 3 on 10 µg of HepG2 cell lysate.

目标描述

~80 kDa observed. The calculated molecular weight is 63 kDa, however Lnk/SH2B adapter protein 3 has been shown as a ~80 kDa band in western blots (Li, Y., et al. (2000). J Immunol. 164:5199-5206.)

外形

Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Affinity purified

储存及稳定性

Stable for 1 year at 2-8°C from date of receipt.

分析说明

Control
HepG2 cell lysate

其他说明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

产品性质

安全信息