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Anti-mA20 Antibody/TNFAIP3, clone 37

品牌
Sigma-Aldrich
货号
MABF220
规格纯度
clone 37, 0.5 mg/mL, from rat
参考价格
6022.61 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
Anti-mA20 Antibody/TNFAIP3, clone 37
Tumor necrosis factor alpha-induced protein 3, TNF alpha-induced protein 3, Putative DNA-binding protein A20, Zinc finger protein A20
产品介绍:

产品说明

一般描述

TNFAIP3/mA20, also known as Tumor necrosis factor alpha-induced protein 3, OTU domain-containing protein 7C, Putative DNA-binding protein A20, or Zinc finger protein A20, and encoded by the gene TNFAIP3/OTUD7C, is an ubiquitin editing enzyme that contains both ubiquitin ligase and deubiquitinase activities. TNFAIP3/mA20 is involved in immune and inflammatory responses signaled by cytokines or pathogens through the Toll-like receptors and ultimately regulating NF-kappa-B activity. TNFAIP3/mA20 is an essential component of the ubiquitin editing protein complex consisting of RNF11, ICTH, and TAX1BP1 and ensures the transient nature of inflammatory signaling. TNFAIP3/mA20 is also a key player in switching of Lys-63 polyubiquitinated chains to Lys-48 polyubiquitinated chains for the subsequent degradation of specific targets as well. TNFAIP3/mA20 is located in the cytoplasm but can be found in the nucleus and lysosome depending upon the microenvironment and stimulus.

免疫原

Recombinant protein corresponding to Mouse mA20/TNFAIP3.

应用

Research Sub Category
Apoptosis - Additional
Detect mA20/TNFAIP3 using this Anti-mA20 Antibody/TNFAIP3, clone 37 validated for use in flow cytometry.
Research Category
Inflammation & Immunology

质量

Evaluated by Flow Cytometry in mouse splenocytes.

Flow Cytometry Analysis: 2 µg of this antibody detected mA20/TNFAIP3 in 1X10E6 mouse splenocytes.

This antibody was produced in collaboration with the Scripps Research Institute.For Scripps Research Institute Validation (Click Here)

目标描述

90 kDa calculated

外形

Purified by Ion-Exchange Chromatography
Purified rat monoclonal IgMκ in buffer containing PBS with 0.05% sodium azide.
Format: Purified

储存及稳定性

Stable for 1 year at 2-8°C from date of receipt.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss32160702
NACRESNA.41

产品性质

质量水平100
生物来源rat
抗体形式purified immunoglobulin
antibody product typeprimary antibodies
克隆37, monoclonal
species reactivitymouse
浓度0.5 mg/mL
technique(s)flow cytometry: suitable
同位素/亚型IgMκ
NCBI登记号NP_033423
UniProt登记号Q60769
运输wet ice

安全信息

储存分类代码12 - Non Combustible Liquids
WGKWGK 2
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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