Anti-MC1R (C-terminal) antibody produced in rabbit

产品说明

免疫原

Synthetic peptide corresponding to a region within amino acids 253 and 317 of MC1-R according to NP_002377

应用

Suggested starting dilutions are as follows: IHC-P: 1:100-1:1000, WB: 1:500-1:3000. Not yet tested in other applications. Optimal working dilutions should be determined experimentally by the end user.

生化/生理作用

This intronless gene encodes the receptor protein for melanocyte-stimulating hormone (MSH). The encoded protein, a seven pass transmembrane G protein coupled receptor, controls melanogenesis. Two types of melanin exist: red pheomelanin and black eumelanin. Gene mutations that lead to a loss in function are associated with increased pheomelanin production, which leads to lighter skin and hair color. Eumelanin is photoprotective but pheomelanin may contribute to UV-induced skin damage by generating free radicals upon UV radiation. Binding of MSH to its receptor activates the receptor and stimulates eumelanin synthesis. This receptor is a major determining factor in sun sensitivity and is a genetic risk factor for melanoma and non-melanoma skin cancer. Over 30 variant alleles have been identified which correlate with skin and hair color, providing evidence that this gene is an important component in determining normal human pigment variation. [provided by RefSeq]

特点和优势

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

外形

0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.

基本信息

产品性质

安全信息

象形图
警示用语：	Warning
危险声明	H317 - H412
预防措施声明	P261 - P272 - P273 - P280 - P302 + P352 - P333 + P313
危险分类	Aquatic Chronic 3 - Skin Sens. 1
储存分类代码	12 - Non Combustible Liquids
WGK	WGK 2