Anti-Megf10 Antibody

产品说明

一般描述

Multiple epidermal growth factor-like domains protein 10 (Megf10) is a type 1 transmembrane protein with multiple EGF-like extracellular domains. Megf10 is highly expressed in the brain, and plays an important role in phacocytosis of apoptotic cells. This role may be performed through the interaction of Megf10 with the ATP-binding cassette transporter (ABCA1) protein. Previous studies have suggested that Megf10 may be involved in the uptake of amyloid β peptides in the brain. Megf10 may therefore play a role Alzheimer’s disease.

特异性

This antibody recognizes Megf10 at the cytoplasmic domain.
Other homologies: Rat (98% sequence homology) and Human (92% sequence homology).

免疫原

Histidine-tagged recombinant protein corresponding to the cytoplasmic domain of mouse Megf10.
Epitope: Cytoplasmic domain

应用

Immunofluorescence Analysis: A representative lot was used by an independent laboratory in P7 caudal brain tissue and retina cells. Image courtesy from the laboratory of Dr. Joshua Sanes, Harvard University.
Research Sub Category
Apoptosis - Additional
Research Category
Apoptosis & Cancer
Detect the Megf10 protein using this Anti-Megf10 validated for use in WB & IF.

质量

Evaluated by Western Blot in mouse retina tissue lysate.

Western Blot Analysis: 1 µg/mL of this antibody detected Megf10 on 10 µg of mouse retina tissue lysate.

目标描述

~130 kDa observed

外形

Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Affinity purified

储存及稳定性

Stable for 1 year at 2-8°C from date of receipt.

分析说明

Control
Mouse retina tissue lysate

其他说明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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