Anti-MEPE Antibody, clone LFMb-33

产品说明

一般描述

The protein with the gene name MEPE and the protein name of Matrix extracellular phosphoglycoprotein or Osteoblast/osteocyte factor 45 (OF45) is an important secreted protein expressed by osteoblasts which promotes mineralization in bone. New research interestingly indicates that cancer cells that over express MEPE/OF45 show an increased resistance to radiation therapy, thus OF45 is being examined as a potentially new target for sensitizing tumor cells to radiochemotherapy. MEPE/OF45 is highly expressed by osteoblasts and osteocytes and my multiple cancer cell types and regulated by growth factors such as FGF-2 which acts to lower expression of the protein in normal cells.

免疫原

Recombinant protein corresponding to human MEPE.

应用

Research Sub Category
Apoptosis - Additional
Western Blotting Analysis: 1.0 µg/mL from a representative lot detected MEPE in 10 µg of SK-N-SH and U2OS cell lysate.
Immunohistochemistry Analysis: A representative lot detected MEPE in human salivary gland tissue (Dent, J., et al. (2004). Research. 83(9):664-670).
Anti-MEPE Antibody, clone LFMb-33 | MABC540 is an antibody against MEPE Antibody for use in Western Blotting, Immunohistochemistry.
Research Category
Apoptosis & Cancer

质量

Evaluated by Western Blotting in HeLa cell lysate.

Western Blotting Analysis: 1.0 µg/mL of this antibody detected MEPE in 10 µg of HeLa cell lysate.

目标描述

~65 kDa observed. The calculated molecular weight of this protein is 58 kDa, but can be observed at ~45-62 kDa due to high glycosylation.

外形

Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Format: Purified
Protein G Purified

储存及稳定性

Stable for 1 year at 2-8°C from date of receipt.

其他说明

Concentration: Please refer to lot specific datasheet.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

产品性质

安全信息