Anti-Mitofilin antibody, Mouse monoclonal

产品说明

一般描述

Mitochondria are essential organelles whose function is critical to homeostasis, energy generation, and cell fate.
Their dysfunction leads to various human diseases. Mitochondria membrane is composed of the outer membrane (OMM) and the inner membrane (IMM) where the electron transport chain machinery takes place and the cristae folds of the mitochondria are formed.1 Mitofilin, a transmembrane IMM protein, is a critical core component of the mitochondrial contact site and cristae organizing system (MICOS).Mitofilin is expressed preferentially in the heart3 but also in the brain4, liver5, kidneys6 and eyes7. It is abundantly found at mitochondrial cristae junctions and is also present within cristae.8,9

特异性

Monoclonal Anti-Mitofilin antibody specifically recognizes human and hamster Mitofilin.

应用

The antibody may be used in various immunochemical techniques including Immunoblotting (~85 kDa) and Immunofluorescence. Detection of the Mitofilin band by Immunoblotting is specifically inhibited by the immunogen.

生化/生理作用

Mitofilin has critical roles in cristae organization, MICOS formation, ATP generation, protein transport, mitochondrial DNA transcription and apoptosis.1

Mitofilin downregulation or misexpression has been associated with various human diseases such as, diabetes, Parkinson′s and Alzheimer′s diseases, heart failure, hepatic carcinoma, gastric cancer and Glaucoma.1

外形

Supplied as a solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide as a preservative.

储存及稳定性

For continuous use, store at 2-8℃ for up to one month. For extended storage, freeze in working aliquots. Repeated freezing and thawing is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.

免责声明

Unless otherwise stated in our catalog  our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

产品性质

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