产品说明
一般描述
MLK1 (MAP3K9) is a serine–threonine kinase of the Mixed-Lineage Kinase (MLK) family capable of activating the c-Jun N-terminal Kinase (JNK)/Mitogen-Activated Protein Kinase (MAPK) pathway and regulating the other two prinicpal MAPK cascades, p38 and extracellular signal regulated kinase (ERK). Immunoblots and mass spectrometry show MLK is threonine phosphorylated in or near the activation loop. Studies show that MLKs play a role in the TGF-beta1-induced cell death mechanism.
免疫原
KLH-conjugated linear peptide corresponding to human MLK1.
应用
Anti-MLK1 Antibody detects level of MLK1 & has been published & validated for use in IH(P).
Research Category
Signaling
Research Sub Category
Kinases & Phosphatases
质量
Evaluated by Immunohistochemistry in colorectal adenocarcinoma tissue.
Immunohistochemistry Analysis: A 1:300 dilution of this antibody detected MLK1 in colorectal adenocarcinoma tissue.
目标描述
121 kDa (isoform 1), 123 kDa (isoform 2) calculated
外形
Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Affinity purified
储存及稳定性
Stable for 1 year at 2-8°C from date of receipt.
分析说明
Control
Colorectal adenocarcinoma tissue
其他说明
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
eCl@ss | 32160702 |
NACRES | NA.41 |
产品性质
生物来源 | rabbit |
质量水平 | 100 |
抗体形式 | affinity isolated antibody |
antibody product type | primary antibodies |
克隆 | polyclonal |
纯化方式 | affinity chromatography |
species reactivity | human |
species reactivity (predicted by homology) | rat (based on 100% sequence homology), rhesus macaque (based on 100% sequence homology), chimpanzee (based on 100% sequence homology), mouse (based on 100% sequence homology) |
technique(s) | immunohistochemistry: suitable (paraffin) |
NCBI登记号 | NP_149132 |
UniProt登记号 | P80192 |
运输 | wet ice |
Gene Information | human ... MAP3K9(4293) |
安全信息
储存分类代码 | 10 - Combustible liquids |
Sigma-Aldrich