产品说明
一般描述
Myeloid/lymphoid or mixed-lineage leukemia 2 (MLL2) belongs to the SET family of proteins. The SET domain of MLL2 confers strong histone 3 lysine 4 methyltransferase activity. MLL2 is part of a large protein complex called activating signal cointegrator-2 complex (ASCOM).
免疫原
Fusion protein corresponding to the C-terminus of human MLL2. The corresponding sequence is identical in mouse and rat MLL2 and shares 85% homology with MLL3.
应用
Monoclonal Anti-MLL2 antibody produced in mouse has been used in immunoblotting and immunofluorescence.
生化/生理作用
MLL2 acts as an epigenetic transcriptional activator during growth and development. It functions as a transcriptional regulator of the beta-globin and estrogen receptor genes. Mutations in this gene are linked to Kabuki syndrome.
外形
0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| NACRES | NA.41 |
产品性质
| 质量水平 | 200 |
| 生物来源 | mouse |
| 偶联物 | unconjugated |
| 抗体形式 | purified from hybridoma cell culture |
| antibody product type | primary antibodies |
| 克隆 | MLL2-A, monoclonal |
| 形式 | buffered aqueous solution |
| 分子量 | antigen ~17 kDa |
| species reactivity | human |
| 浓度 | ~1.0 mg/mL |
| technique(s) | indirect immunofluorescence: suitable western blot: 0.2-0.5 μg/mL using using human MLL2 partial fusion protein (immunogen) |
| 同位素/亚型 | IgG1 |
| 运输 | dry ice |
| 储存温度 | −20℃ |
| Gene Information | human ... MLL2(8085) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
