产品说明
一般描述
TMEM173 (transmembrane protein 173) gene is mapped to human chromosome 5q31.2. The encoded protein localizes in the endoplasmic reticulum.
免疫原
MPYS antibody was raised against a 17 amino acid peptide near the carboxy terminus of human MPYS.
生化/生理作用
The innate immune response against the viral and bacterial infections is mostly regulated by TMEM173 (transmembrane protein 173), also known as stimulator of interferon genes (STING). It is considered as an important adaptor protein for cytosolic DNA sensing pathways. Downregulation of the gene was observed in tumor tissues. TMEM173 acts as a pattern recognition receptor and identifies pathogen-associated molecular patterns. It also mediates signal transduction pathways. TMEM173 is significantly associated with immunity and inflammation.
特点和优势
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
目标描述
MPYS is a recently identified plasma membrane tetraspanner that is associated with major histocompatibility complex class II (MHC-II) and mediates its transduction of apoptotic signals. It has also been found to be associated with VISA, a mitochondrial protein that acts as an adaptor in virus-triggered signaling. MPYS also interacts with IRF3 and recruits the kinase TBK1 to the VISA-associated complex, acting as a critical mediator of virus-triggered IRF3 activation and interferon (IFN) expression. It is thought that the binding of nucleic acid to the innate immune protein RIG-I causes complex formation between RIG-I, VISA, and MPYS. This complex then recruits TBK1 to phosphorylate IRF3 which then directly activates IFN transcription. At least three isoforms of MPYS are known to exist.
联系
The action of this antibody can be blocked using blocking peptide SBP3500076.
外形
Supplied at approx. 1 mg/mL in phosphate buffered saline containing 0.02% sodium azide.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| NACRES | NA.41 |
产品性质
| 生物来源 | rabbit |
| 质量水平 | 100 |
| 偶联物 | unconjugated |
| 抗体形式 | affinity isolated antibody |
| antibody product type | primary antibodies |
| 克隆 | polyclonal |
| 形式 | buffered aqueous solution |
| 分子量 | predicted mol wt 31-42 kDa |
| species reactivity | mouse, human |
| technique(s) | immunocytochemistry: suitable indirect ELISA: suitable western blot: suitable |
| NCBI登记号 | NP_938023 |
| UniProt登记号 | Q86WV6 |
| 运输 | dry ice |
| 储存温度 | −20℃ |
| Gene Information | human ... TMEM173(340061) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | WGK 2 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
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