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Anti-MR-Pro ADM antibody, Mouse monoclonal

品牌
Sigma-Aldrich
货号
SAB4200700
规格纯度
clone MR2.1, purified from hybridoma cell culture
参考价格
6732.28 *本价格含增值税费
促销
服务
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数量
-+
产品名称:
Anti-MR-Pro ADM antibody, Mouse monoclonal
Midregional proadrenomedullin
产品介绍:

产品说明

一般描述

Anti-MR-Pro ADM antibody, Mouse monoclonal (MidRegional pro-Adrenomedullin) (mouse IgG2a isotype) is derived from the hybridoma MR2.1 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a synthetic peptide corresponding to the internal region of human Adrenomedullin (ADM), conjugated to KLH. The precursor peptide of Adrenomedullin (ADM), prepro-ADM, is processed to the circulating form of ADM. During this processing, other peptides are also being generated; PAMP (proadrenomedullin N-terminal 20 peptide) with suggested hypotensive effect, and MR-pro ADM (Mid-Regional pro-Adrenomedullin) which consists of 47 amino acid-propeptide.

免疫原

Synthetic peptide corresponding to the internal region of human Adrenomedullin (ADM), conjugated to KLH.

应用

Anti-MR-Pro ADM antibody has been used in immunoblotting, immunohistochemistry.

生化/生理作用

MR-pro ADM (MidRegional pro-Adrenomedullin) has been suggested as a biomarker for plasma concentrations of Adrenomedullin as it is stoichiometrically generated and relatively stable in the plasma. Increased levels of MR-pro ADM were associated with an increased risk of mortality and morbidity in patients with heart failure, independent of natriuretic peptides. In dialysis patients MR-pro ADM and MR-pro ANP were shown to be associated with mortality in general and particularly with cardiovascular related mortality, with the highest risk when both parameters were elevated.

外形

Solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide

法律信息

ExtrAvidin is a registered trademark of sigma-aldrich Co. LLC

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

NACRESNA.41

产品性质

质量水平200
生物来源mouse
偶联物unconjugated
抗体形式purified immunoglobulin
antibody product typeprimary antibodies
克隆MR2.1, monoclonal
形式buffered aqueous solution
species reactivityhuman
浓度~1 mg/mL
technique(s)immunoblotting: 1-2 μg/mL using human recombinant peptide of MR-Pro ADM (amino acid 45-92)
immunohistochemistry: 2.5-5 μg/mL using Biotin/ExtrAvidin®-Peroxidase staining system of heat-retrieved formalin-fixed, paraffin-embedded human Pancreas sections
同位素/亚型IgG2a
UniProt登记号P35318
运输dry ice
储存温度−20℃
Gene Informationhuman ... ADM(133)

安全信息

储存分类代码12 - Non Combustible Liquids
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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