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Anti-MTHFS antibody produced in rabbit

品牌
Sigma-Aldrich
货号
HPA008067
规格纯度
Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
参考价格
6389.73 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
Anti-MTHFS antibody produced in rabbit
Anti-5-Formyltetrahydrofolate cyclo-ligase antibody produced in rabbit
Anti-5,10-Methenyl-tetrahydrofolate synthetase antibody produced in rabbit
Anti-Methenyl-THF synthetase antibody produced in rabbit
产品介绍:

产品说明

一般描述

MTHFS (5,10-methenyltetrahydrofolate synthetase) gene encodes a protein of 203-amino-acids that has a molar mass of 23,229Da. This gene is mapped to human chromosome 15q25.1.

免疫原

5-Formyltetrahydrofolate cyclo-ligase recombinant protein epitope signature tag (PrEST)

应用

Anti-MTHFS antibody produced in rabbit, a Prestige Antibody, is developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org). Each antibody is tested by immunohistochemistry against hundreds of normal and disease tissues. These images can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. The antibodies are also tested using immunofluorescence and western blotting. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.

生化/生理作用

MTHFS (5,10-methenyltetrahydrofolate synthetase) gene encodes an enzyme that catalyzes the irreversible conversion of 5-formyltetrahydrofolate to 5,10-methenyltetrahydrofolate. This reaction is ATP-dependent and contributes to tetrahydrofolate metabolism. It regulates the flow of carbon through the folate-dependent one-carbon metabolic network. This network in essential for the supply of carbon in the biosynthesis of purines, thymidine and amino acids. Overexpression of the encoded protein causes an increased folate turnover rate and folate depletion. The expression of this protein has been found to be enhanced in animal tumors, where it increases de novo purine synthesis and confers partial resistance to antifolate purine synthesis inhibitors. It is also found to increase rates of folate catabolism in mammalian cell cultures.

特点和优势

Prestige Antibodies® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:

  • IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
  • Protein array of 364 human recombinant protein fragments.

联系

Corresponding Antigen APREST71217.

外形

Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide

法律信息

Prestige Antibodies is a registered trademark of sigma-aldrich Co. LLC

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

人类蛋白质图谱编号HPA008067    Human Protein Atlas characterization data

产品性质

生物来源rabbit
质量水平100
偶联物unconjugated
抗体形式affinity isolated antibody
antibody product typeprimary antibodies
克隆polyclonal
产品线Prestige Antibodies® Powered by Atlas Antibodies
形式buffered aqueous glycerol solution
species reactivityhuman
包装antibody small pack of 25 μL
technique(s)immunoblotting: 0.04-0.4 μg/mL
immunohistochemistry: 1:50-1:200
免疫原序列VLPKTSWNIPQPGEGDVREEALSTGGLDLIFMPGLGFDKHGNRLGRGKGYYDAYLKRCLQHQEVKPYTLALAFKEQICLQVPVNENDMKVDEVLYEDSSTA
UniProt登记号P49914
运输wet ice
储存温度−20℃
Gene Informationhuman ... MTHFS(10588)

安全信息

储存分类代码10 - Combustible liquids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable
个人防护装备Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Sigma-Aldrich

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