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Anti-MTMR1 (N-term) antibody produced in rabbit

品牌
Sigma-Aldrich
货号
SAB1300357
规格纯度
IgG fraction of antiserum, buffered aqueous solution
参考价格
5045.46 *本价格含增值税费
促销
服务
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  • 包邮
  • 增值税票
数量
-+
产品名称:
Anti-MTMR1 (N-term) antibody produced in rabbit
产品介绍:

产品说明

一般描述

MTM1 gene mutations cause X-linked myotubular myopathy. The corresponding protein, myotubularin, contains the consensus active site of tyrosine phosphatases (PTP) and is a tyrosine/serine phosphatase. The 3.7-kb MTMR1 mRNA is expressed ubiquitously. An additional 3.1-kb transcript was detected only in placenta. Analysis of the genomic region containing MTM1 and MTMR1 reveals that the 2 genes share a similar structure, suggesting that they are related and arose from an intrachromosomal gene duplication. The 2 main MTMR1 protein muscular isoforms, like myotubularin, dephosphorylate PI(3)P in vitro. There is a striking reduction in the level of the muscle-specific isoform and the appearance of an abnormal MTMR1 transcript in cultured differentiated muscle cells and in skeletal muscle from congenital myotonic dystrophy patients. MTMR1 may play a role in muscle formation, and may represent another target for abnormal mRNA splicing in myotonic dystrophy.

免疫原

MTMR1 (Q9Z2C4, 6-42)
This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human MTMR1.

外形

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.

基本信息

NACRESNA.41

产品性质

生物来源rabbit
质量水平200
偶联物unconjugated
抗体形式IgG fraction of antiserum
antibody product typeprimary antibodies
克隆polyclonal
形式buffered aqueous solution
species reactivityhuman
technique(s)indirect ELISA: 1:1000
NCBI登记号NP_058681
UniProt登记号Q13613
运输dry ice
储存温度−20℃
Gene Informationhuman ... MTMR1(53332)

安全信息

储存分类代码12 - Non Combustible Liquids
WGKnwg
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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