Anti-Myb Binding Protein 1A Antibody

产品说明

一般描述

Myb-binding protein 1A (MYBBP1A) interacts with sequence specific DNA-binding proteins in order to activate or repress transcription. Transcriptional repression via Myb-binding protein 1A is thought to be mediated by histone deacetylase activity (HDAC activity).

特异性

This antibody detects the full length and cleaved forms of Myb Binding Protein 1A.

免疫原

GST-tagged recombinant protein corresponding to human Myb Binding Protein 1A.

应用

Anti-Myb Binding Protein 1A Antibody is a highly specific rabbit polyclonal antibody, that targets Myb-binding protein 1A & has been tested in western blotting & ICC.
Immunocytochemistry Analysis: A 1:500 dilution from a representative lot detected Myb Binding Protein 1A in diploid human lung embryonic fibroblasts (Prof. Atilla Nemeth, University of Regensburg, Germany.).

Immunocytochemistry Analysis: A representative lot from an independent laboratory detected Myb Binding Protein 1A in HeLa cells (Hochstatter, J., et al. (2012). J Biol Chem. 287(29):24365-24377.).

Chromatin Immunoprecipitation (ChIP) Analysis: A representative lot from an independent laboratory immunoprecipitated Myb Binding Protein 1A in ChIP (Hochstatter, J., et al. (2012). J Biol Chem. 287(29):24365-24377.).

质量

Evaluated by Western Blotting in A431 cell lysate.

Western Blotting Analyis: A 1:1,000 dilution from a representative lot detected Myb Binding Protein 1A in 10 µg of A431 cell lysate.

目标描述

~160 kDa observed. Uncharacterized band(s) may be observed in some cell lysates. The full length of this protein is observed at ~160 kDa; however, it is proteolytically cleaved into ~140 kDa and ~67 kDa fragments (Hochstatter, J., et al. (2012). J Biol Chem. 287(29):24365-24377.; Mori, S., et al. (2012). PLoS One. 7(10):e39723.).

外形

Unpurified

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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