Anti-NDRG3 antibody produced in rabbit

产品说明

一般描述

NDRG3 (N-myc downstream-regulated gene 3 protein) is a novel member of N-myc down-regulated gene (NDRG) family mapped to human chromosomal location 20q11.21-q11.23. It is abundantly expressed in brain, prostate, ovary, and testis tissues. It is localized to the outer layers of seminiferous epithelium.

免疫原

The antiserum was produced against synthesized peptide derived from human NDRG3.

Immunogen Range: 206-255

应用

Anti-NDRG3 antibody produced in rabbit is suitable for immunohistochemistry and western blot.

生化/生理作用

N-myc downstream-regulated gene 3 protein (NDRG3) is involved in prostate cancer cell growth in vitro and in vivo. It acts as an androgen regulated and prostate enriched gene during controlling of cancer cell growth. Thus, overexpression of NDRG3 has been linked to the malignant phenotype of tumors. In hepatitis B virus (HBV)-related hepatocellular carcinoma cell line, NDRG3 gene is inversely expressed with the miR-122 expression. Thus, it has been reported that in conjugation with miR-122, NDRG3 can be a potential therapeutic marker for hepatocellular carcinoma (HCC). Prominent localization of NDRG3 in the epithelium cells indicate its role in spermatogenesis. It also plays an important role in lactate-induced hypoxia signaling pathway in hypoxia. Its protein level expression in cell is negatively regulated by oxygen, whereas, whereas excess lactate produced under prolonged hypoxia blocks its proteasomal degradation by binding to NDRG3.

特点和优势

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外形

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

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