产品说明

一般描述

NEU3 sialidase also called neuraminidase, is an enzyme located on the outer leaflet of plasma membrane, which catalyses the removal of sialic acids present on the gangliosides thus providing cell to cell interactions. The NEU3 sialidase gene is located on human chromosome 11q 13s.5 and this protein consists of 428 amino acids.

免疫原

sialidase 3 (membrane sialidase) recombinant protein epitope signature tag (PrEST)

应用

All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry.

The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.

生化/生理作用

NEU3 sialidase regulates neuronal differentiation, apoptosis and adhesion. Neu3 sialidase helps cell differentiation, carcinogenesis and mediates cellular response to hypoxic stress. NEU3 sialidase directly interacts with and regulates epidermal growth factor receptor (EGFR).Overexpression of NEU3 sialidase stimulates extracellular regulated kinase (ERK) and protein kinase B (AKT/PKB) pathways, which is inhibited or decreased by gefitinib treatment respectively. NEU3 sialidase invades glioblastoma cells by regulating calpain activity and disassembly of focal adhesion. Many types of cancers like colon and prostate carcinomas exhibit an upregulation of NEU3.

特点和优势

Prestige Antibodies^® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies^® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:

• IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
• Protein array of 364 human recombinant protein fragments.

联系

Corresponding Antigen APREST80678.

外形

Solution in phosphate buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide.

法律信息

Prestige Antibodies is a registered trademark of sigma-aldrich Co. LLC

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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