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位置:首页 > 品牌 > Sigma-Aldrich > Anti-NOD1/CARD4 Antibody, clone 021

Anti-NOD1/CARD4 Antibody, clone 021

品牌
Sigma-Aldrich
货号
MABF215
规格纯度
clone 021, 1 mg/mL, from mouse
参考价格
5016.79 *本价格含增值税费
促销
服务
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数量
-+
产品名称:
Anti-NOD1/CARD4 Antibody, clone 021
Nucleotide-binding oligomerization domain-containing protein 1, Caspase recruitment domain-containing protein 4
产品介绍:

产品说明

一般描述

NOD1/CARD4, also known as Nucleotide-binding oligomerization domain-containing protein 1, or Caspase recruitment domain-containing protein 4, and encoded by the gene NOD1/CARD4, is an important apoptosis mediating protein that enhances caspase-9-mediated apoptosis. NOD1/CARD4 also mediates cellular responsiveness to intracellular bacterial LPS and forms an intracellular sensing system along with another protein called ARHGEF2 for the detection of microbial effectors during cell invasion by pathogens. NOD1/CARD4 is a homodimer that is found in the cytoplasm but also associated with the cell membrane in particular cells such as polarized epithelial cells. NOD1/CARD4 is expressed in many tissues including heart, skeletal muscle, and pancreas. As part of the innate immune system NOD1/CARD4 is part of a family of proteins that are responsible for the initial response of an organism to potentially harmful stressors, pathogens or tissue injury, and accordingly plays an essential role in the pathogenesis of many inflammatory processes, including some cardiovascular diseases.

免疫原

Epitope: CARD domain
Recombinant protein corresponding to the CARD domain of human NOD1/CARD4.

应用

Flow Cytometry Analysis: 2 µg of this antibody from a representative lot detected NOD1/CARD4 in 1X10E6 Jurkat cells. This antibody was produced in collaboration with the Scripps Research Institute.
Research Sub Category
Immunoglobulins & Immunology
Anti-NOD1/CARD4 Antibody, clone 021 is an antibody against NOD1/CARD4 for use in western blotting & flow cytometry.
Research Category
Inflammation & Immunology

质量

Evaluted by Western Blotting in human spleen tissue lysate.

Western Blotting Analysis: 1 µg/mL of this antibody detected NOD1/CARD4 in 10 µg of human spleen tissue lysate.

This antibody was produced in collaboration with the Scripps Research Institute. For Scripps Research Institute Validation (Click Here)

目标描述

~125 kDa observed. The calculated molecular weight of this protein is 108 kDa, but has been observed at ~125 kDa in some cell lysates. An IgG heavy chain may be observed at 55 kDa

外形

Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Format: Purified
Protein G Purified

储存及稳定性

Stable for 1 year at 2-8°C from date of receipt.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss32160702
NACRESNA.41

产品性质

质量水平100
生物来源mouse
抗体形式purified immunoglobulin
antibody product typeprimary antibodies
克隆021, monoclonal
species reactivityhuman
浓度1 mg/mL
technique(s)flow cytometry: suitable
western blot: suitable
同位素/亚型IgG1κ
NCBI登记号NP_006083
UniProt登记号Q9Y239
运输wet ice

安全信息

储存分类代码12 - Non Combustible Liquids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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