Anti-Numb Antibody, clone 6G10.1

产品说明

一般描述

Numb plays a key role in neurogenesis and in cell fate decisions. It maintains self-renewal properties in neural progenitor cells, which are also called radial glial cells (RGCs). It functions through inhibition of Notch signaling. Additionally, it is suggested to mediate local repair in brain ventricular wall damage.

特异性

This antibody recognizes Numb isoforms 1 and 2.

免疫原

KLH-conjugated linear peptide corresponding to human Numb isoforms 1 and 2.

应用

Detect Numb using this Anti-Numb Antibody, clone 6G10.1 validated for use in WB & IC.
Research Category
Neuroscience
Research Sub Category
Developmental Neuroscience
Immunocytochemistry Analysis: A 1:500 dilution from a representative lot detected Numb in HeLa and A431 cells.

质量

Evaluated by Western Blot in A431 cell lysate.

Western Blot Analysis: 1 µg/mL of this antibody detected Numb in 10 µg of A431 cell lysate.

目标描述

~70 kDa observed. Uniprot describes four isoforms at ~71 kDa (isoform 1), ~66 kDa (isoform 2), ~69 kDa (isoform 3), and ~65 kDa (isoform 4).

外形

Purified by Ion-Exchange Chromatography
Format: Purified
Purified mouse monoclonal IgMκ in buffer containing PBS with 0.05% sodium azide.

储存及稳定性

Stable for 1 year at 2-8°C from date of receipt.

分析说明

Control
A431 cell lysate

其他说明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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