产品说明
一般描述
Octamer-binding transcription factor 3 (OCT3)/OCT4 is encoded by the gene spanning 1420 bases of genomic DNA mapped to human chromosome 6p21.33. OCT3/OCT4 is a transcription factor that belongs to the transcription Pit-Oct-Unc (POU)family. This protein contains a POU-specific homeodomain and DNA-binding domain. Anti-OCT3 antibody detects endogenous levels of total OCT3 protein.
Anti-OCT3 Antibody detects endogenous levels of total OCT3 protein.
免疫原
The antiserum was produced against synthesized peptide derived from human OCT3.
Immunogen Range: 191-240
应用
Anti-OCT3 antibody produced in rabbit may be used in immunohistochemistry at 1:100 dilution and immunoblot at 1:1000 dilution.
生化/生理作用
Octamer-binding transcription factor 3 (OCT3)/OCT4 plays a vital role in the self-renewal and pluripotency of embryonic stem cells. It is involved in the regulation of embryonic development and cell fate determination. Overexpression of OCT4 gene aids in the progression of various types of human cancers by increasing tumorigenicity and enhancing resistance to chemotherapeutics. OCT4 expression acts as a potential cancer diagnosis and prognosis biomarker. Reduced expression of the OCT4 gene suppresses the growth of pancreatic cancer cells by blocking the AKT pathway. Therefore, OCT4 protein may be used as an effective therapeutic target for pancreatic cancer treatment.
特点和优势
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外形
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| MDL编号 | MFCD02263853 |
| NACRES | NA.41 |
产品性质
| 生物来源 | rabbit |
| 质量水平 | 100 |
| 偶联物 | unconjugated |
| 抗体形式 | affinity isolated antibody |
| antibody product type | primary antibodies |
| 克隆 | polyclonal |
| 形式 | buffered aqueous solution |
| 分子量 | antigen 38 kDa |
| species reactivity | mouse, rat, human |
| 浓度 | ~1 mg/mL |
| technique(s) | ELISA: 1:10000 immunohistochemistry: 1:50-1:100 western blot: 1:500-1:1000 |
| NCBI登记号 | Q01860 |
| UniProt登记号 | Q01860 |
| application(s) | research pathology |
| 运输 | wet ice |
| 储存温度 | −20℃ |
| Gene Information | human ... POU5F1(5460) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | nwg |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
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