产品说明
一般描述
OTU ubiquitin aldehyde binding 2 (OTUB2) is a de-ubiquitinating enzyme, which belongs to the ovarian tumor protease (OTU) subfamily of deubiquitinylases. It has an ovarian tumor (OTU) domain. OTUB2 gene is mapped to human chromosome 14q32.
免疫原
OTUB2 (NP_075601.1, 1 a.a. ~ 234 a.a) full-length human protein.
Sequence
MSETSFNLISEKCDILSILRDHPENRIYRRKIEELSKRFTAIRKTKGDGNCFYRALGYSYLESLLGKSREIFKFKERVLQTPNDLLAAGFEEHKFRNFFNAFYSVVELVEKDGSVSSLLKVFNDQSASDHIVQFLRLLTSAFIRNRADFFRHFIDEEMDIKDFCTHEVEPMATECDHIQITALSQALSIALQVEYVDEMDTALNHHVFPEAATPSVYLLYKTSHYNILYAADKH
生化/生理作用
OTU ubiquitin aldehyde binding 2 (OTUB2) possesses deubiquitinating enzymes (DUB) activity. It is capable of cleaving polyubiquitin chains, that are differently linked. It plays an important role in regulating the degradation of GLI family zinc finger 2 (Gli2) protein. OTUB2 can inhibit the death of human β cells. It is involved in immunity and viral infection. This protein can modulate nuclear factor κB (NF-κB) signaling pathway. OTUB2 might be associated with endometrial cancer.
外形
Solution in phosphate buffered saline, pH 7.4
基本信息
| NACRES | NA.41 |
产品性质
| 生物来源 | rabbit |
| 质量水平 | 100 |
| 偶联物 | unconjugated |
| 抗体形式 | purified immunoglobulin |
| antibody product type | primary antibodies |
| 克隆 | polyclonal |
| 形式 | buffered aqueous solution |
| 分子量 | antigen 27.2 kDa |
| species reactivity | human |
| technique(s) | immunofluorescence: suitable western blot: 1 μg/mL |
| NCBI登记号 | NM_023112.2 |
| UniProt登记号 | Q96DC9 |
| 运输 | dry ice |
| 储存温度 | −20℃ |
| Gene Information | human ... OTUB2(78990) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
