产品说明
一般描述
Anti-OVOL1 antibody detects endogenous levels of total OVOL1 protein.
The OVOL1 (ovo like transcriptional repressor 1) gene is mapped to human chromosome 11q13.1. It is widely conserved. In mammals, the gene encodes for C2H2 zinc finger transcription factor. It is predominantly expressed in the human placenta and in the inner root sheath of the hair follicle, suprabasal layer of the epidermis, the ductal portion of the eccrine glands and mature sebocytes of the skin.{36] The protein is localized to cytoplasm.
免疫原
The antiserum was produced against synthesized peptide derived from human OVOL1.
Immunogen Range: 1-50
生化/生理作用
The protein encoded by the OVOL1 (ovo like transcriptional repressor 1) gene regulates proliferation and differentiation of epithelial cells. This protein is homologous to that in Drosophila species, which regulates trophoblast differentiation. OVOL1 is known to take part in epidermal keratinisation by inducing differentiation. OVOL1 is associated with atopic dermatitis. OVOL1 is associated with skin morphogenesis and tumorigenesis.
特点和优势
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外形
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
基本信息
| NACRES | NA.41 |
产品性质
| 生物来源 | rabbit |
| 质量水平 | 100 |
| 偶联物 | unconjugated |
| 抗体形式 | affinity isolated antibody |
| antibody product type | primary antibodies |
| 克隆 | polyclonal |
| 形式 | buffered aqueous solution |
| 分子量 | antigen 30 kDa |
| species reactivity | human, mouse |
| 浓度 | ~1 mg/mL |
| technique(s) | ELISA: 1:40000 western blot: 1:500-1:1000 |
| NCBI登记号 | O14753 |
| UniProt登记号 | O14753 |
| 运输 | wet ice |
| 储存温度 | −20℃ |
| Gene Information | human ... OVOL1(5017) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | nwg |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
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