产品说明
一般描述
The PRKN (parkin RBR E3 ubiquitin protein ligase) gene, also referred to as PARK2, is mapped to human chromosome 6q25.2–27. It is one of the largest genes in the human genome spanning a length of 1.53Mb. The gene consists of 12 exons and encodes a protein of 465 amino acids. It is broadly expressed in several tissues, including neurons, astrocytes, lung, colon and testes.
Anti-Parkin Antibody detects endogenous levels of total Parkin protein.
免疫原
The antiserum was produced against synthesized peptide derived from human Parkin.
Immunogen Range: 101-150
生化/生理作用
The PRKN (parkin RBR E3 ubiquitin protein ligase) gene encodes an E3 ubiquitin ligase that is involved in the maintenance of dopamine (DA) neuronal homeostasis. It ubiquitinates target proteins by interacting with ubiquitin-conjugating enzymes, such as UBCH7 (Ubiquitin-conjugating enzyme E2 L3) and UBCH8 (Ubiquitin/ISG15-conjugating enzyme E2 L6). Mutations in this gene have been linked to early-onset and progression of Parkinson′s Disease. Variations in this gene have also been associated with glioblastoma and other human malignancies.
特点和优势
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
外形
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| MDL编号 | MFCD02263896 |
| NACRES | NA.41 |
产品性质
| 生物来源 | rabbit |
| 质量水平 | 100 |
| 偶联物 | unconjugated |
| 抗体形式 | affinity isolated antibody |
| antibody product type | primary antibodies |
| 克隆 | polyclonal |
| 形式 | buffered aqueous solution |
| 分子量 | antigen 51 kDa |
| species reactivity | human |
| 浓度 | ~1 mg/mL |
| technique(s) | ELISA: 1:10000 immunohistochemistry: 1:50-1:100 western blot: 1:500-1:1000 |
| NCBI登记号 | O60260 |
| 运输 | wet ice |
| 储存温度 | −20℃ |
| Gene Information | human ... PRKN2(5071) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | nwg |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
