产品说明
一般描述
Pyruvate dehydrogenase kinase 3 (PDK3) is a nuclear-coded protein localized in the mitochondrial matrix. The protein is expressed in testis, kidney and brain. The PDK3 gene is located on human chromosome Xp22.11.
免疫原
PDK3 (AAH15948, 174 a.a. ~ 263 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
GDTNPVHPKHIGSIDPTCNVADVVKDAYETAKMLCEQYYLVAPELEVEEFNAKAPDKPIQVVYVPSHLFHMLFELFKNSMRATVELYEDR
生化/生理作用
Pyruvate dehydrogenase kinase 3 (PDK3) regulates pyruvate dehydrogenase complex (PDC) by reversible phosphorylation. Mutations in this gene is associated with X-linked dominant CMT (Charcot-Marie-Tooth disease) type 6 (CMTX6). PDC catalyses the oxidative decarboxylation of pyruvate to acetyl-CoA. Hypoxia-inducible factor-1 (HIF-1) induced PDK3 plays an important role in metabolic switch during cancer progression and drug resistance in cancer therapy.
外形
Solution in phosphate buffered saline, pH 7.4
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| NACRES | NA.41 |
产品性质
| 质量水平 | 100 |
| 生物来源 | mouse |
| 偶联物 | unconjugated |
| 抗体形式 | purified immunoglobulin |
| antibody product type | primary antibodies |
| 克隆 | 1G11, monoclonal |
| 形式 | buffered aqueous solution |
| 分子量 | antigen 35.31 kDa |
| species reactivity | human |
| technique(s) | indirect ELISA: suitable western blot: 1-5 μg/mL |
| 同位素/亚型 | IgG1 |
| NCBI登记号 | BC015948 |
| UniProt登记号 | Q15120 |
| 运输 | dry ice |
| 储存温度 | −20℃ |
| Gene Information | human ... PDK3(5165) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
