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Anti-phospho MEKK5, (Thr845), clone PA214 Antibody

品牌
Sigma-Aldrich
货号
MABS494
规格纯度
clone PA214, from rabbit
参考价格
5520.38 *本价格含增值税费
促销
服务
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数量
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产品名称:
Anti-phospho MEKK5, (Thr845), clone PA214 Antibody
MEKK5, Apoptosis signal-regulating kinase 1, MAPK/ERK kinase kinase 5, ASK-1, MEK kinase 5, MEKK 5, ASK1
产品介绍:

产品说明

一般描述

MEKK5 (MAP3K5) is a key kinase for our innate immunity and for mediating cellular signaling cascades evoked by changes in the external cellular environment. As such, MEKK5 is critical for cell fate during development, apoptosis, and cell survival as well as in modulating the host defense responses from a wide range of pathogens. MEKK5 acts as an upstream activator of the MKK/JNK signaling pathways and the p38 MAPK signaling pathways that ultimately results in activating multiple kinases such as MAP2K3/Mkk3 or MKK6/MMK7. Activation of MMEKK5 is via phosphorylation of Thr-845 within the activation loop via the recently discovered kinase MAP3K6 which forms a complex with MEKK5 and also stabilizes the protein. Expression is widespread and localized in the cytoplasmic in the perinuclear endoplasmic reticulum region.

免疫原

linear peptide corresponding to Human phospho MEKK5 (Thr 845).

应用

Anti-phospho MEKK5, (Thr845), clone PA214 | MABS494 is an antibody against phospho MEKK5 for use in Western Blotting.
Research Category
Signaling
Research Sub Category
Immunological Signaling

质量

Evaluated by Western Blotting on HEK293A lysate
Western Blotting Analysis: 4 µg/mL dilution of this antibody detected phosphorylated MEKK5 protein in 10 µg of H2O2 treated Hek293A cell lysate

目标描述

~160 kDa observed

外形

Format: Purified
Purified rabbit monoclonal supernatant in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Protein G Purified

储存及稳定性

Stable for 1 year at 2-8°C from date of receipt.

其他说明

Concentration: Please refer to lot specific datasheet.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss32160702
NACRESNA.41

产品性质

生物来源rabbit
质量水平100
抗体形式purified antibody
antibody product typeprimary antibodies
克隆PA214, monoclonal
species reactivitymouse, human
technique(s)western blot: suitable
NCBI登记号NP_005914
UniProt登记号Q99683
运输wet ice

安全信息

储存分类代码12 - Non Combustible Liquids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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