产品说明
一般描述
Arrestin 1 (ARRB1) is also termed as β-arrestin-1. This is a cytoplasmic adaptor protein located on human chromosome 11q13.
免疫原
The antiserum was produced against synthesized peptide derived from human Arrestin 1 around the phosphorylation site of Ser412.
Immunogen Range: 369-418
生化/生理作用
Arrestin 1 (ARRB1) participates in DNA damage accumulation and cell apoptosis. Deletion of ARRB1 blocks DDR (DNA damage response) pathway activation. During hypoxia, ARRB1 controls breast cancer cell survival with the help of HIF-1 transcription factor. This gene can act as a scaffold and an adaptor in receptor endocytosis and signal transduction.
特点和优势
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外形
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
产品性质
| 生物来源 | rabbit |
| 质量水平 | 100 |
| 偶联物 | unconjugated |
| 抗体形式 | affinity isolated antibody |
| antibody product type | primary antibodies |
| 克隆 | polyclonal |
| 形式 | buffered aqueous solution |
| 分子量 | antigen 47 kDa |
| species reactivity | rat, mouse, human |
| 浓度 | ~1 mg/mL |
| technique(s) | ELISA: 1:1000 immunohistochemistry: 1:50-1:100 western blot: 1:500-1:1000 |
| NCBI登记号 | P49407 |
| UniProt登记号 | P49407 |
| 运输 | wet ice |
| 储存温度 | −20℃ |
| Gene Information | human ... ARRB1(408) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
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