产品说明
一般描述
Calmodulin 3 (CALM3) encodes calmodulin (CaM) protein 3 which is expressed five folds more than CALM1 and CALM2. CALM3 promoter has high GC content and no TATA box like that of housekeeping gene. CALM3 contains several pro-alpha1 (AP1) and pro-alpha2 (AP2) consensus sites and several CAAT regions. CALM3 also has clusters of specificity protein 1 (SP1) transcription factor. In human chromosome, the gene is localized on 19q13.32.
特异性
The antibody detects endogenous level of Calmodulin only when phosphorylated at threonine 79/serine 81.
免疫原
Peptide sequence around phosphorylation site of threonine79/serine81(K-D-T(p)-D-S(p)-E-E) derived from Human Calmodulin .
生化/生理作用
Calmodulin (CaM) encoded by Calmodulin 3 (CALM3) senses Ca2+ and binds to free signal-transducing protein that regulates Cav1.2 L-type calcium channel and deactivates Cav1.2 when CaM binds to free Ca2+. A sporadic mutation in CALM3 might be the cause for long QT syndrome, a disorder of ventricular myocardial repolarization, characterized by prolonged heart rate. CALM3 expression is higher in teratoma cells. CALM3 is a potential biomarker to dysregulate the melanoma cancer genes. Polymorphism in CALM3 is a potential modifier gene for familial hypertrophic cardiomyopathy.
特点和优势
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
外形
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| NACRES | NA.41 |
产品性质
| 生物来源 | rabbit |
| 质量水平 | 100 |
| 抗体形式 | affinity isolated antibody |
| antibody product type | primary antibodies |
| 克隆 | polyclonal |
| 形式 | buffered aqueous solution |
| 分子量 | 17 kDa |
| species reactivity | human, mouse, rat |
| 浓度 | 1.0 mg/mL |
| technique(s) | western blot: 1:500-1:1000 (Cell Lysate) |
| 同位素/亚型 | IgG |
| 登记号 | NP_005175.2 |
| UniProt登记号 | P0DP25 |
| 运输 | wet ice |
| 储存温度 | −20℃ |
| Gene Information | human ... CALM3(808) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
