产品说明

一般描述

Caspase-8 (CASP8) is a member of the cysteine aspartate-specific proteases family. It is produced in the cell as procaspase-8, a sluggish zymogen. Procaspase-8 has a long prodomain, carrying two major protein interaction domains, DED₁ and DED₂, followed by one large (p18) and one small (p10) catalytic subunit. CASP8 is mapped to human chromosome 2q33.

免疫原

The antiserum was produced against synthesized peptide derived from human Caspase 8 around the phosphorylation site of Tyr380.

Immunogen Range: 346-395

生化/生理作用

Caspase-8 (CASP8) is involved in apoptosis, inflammation and cellular differentiation. It activates programmed cell death, after death receptor ligation. Casp8 is essential for the clonal expansion of T and B cell. It also participates in lymphocyte homeostasis.

特点和优势

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

外形

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

产品性质

安全信息