产品说明
一般描述
This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells.
免疫原
A synthetic phosphorylated peptide around S166 of human MDM2 (NP_002383.2).
外形
PBS with 0.02% sodium azide,50% glycerol,pH7.3.
储存及稳定性
Store at -20℃. Avoid freeze / thaw cycles.
产品性质
| 生物来源 | rabbit |
| 质量水平 | 100 |
| 抗体形式 | affinity isolated antibody |
| antibody product type | primary antibodies |
| 克隆 | polyclonal |
| 形式 | buffered aqueous solution |
| 分子量 | 11-14 24-55 |
| species reactivity | rat, mouse, human |
| 浓度 | 0.63 mg/ml |
| technique(s) | immunofluorescence: 1:50-1:100 western blot: 1:500-1:1000 |
| UniProt登记号 | Q00987 |
| 运输 | wet ice |
| 储存温度 | −20℃ |
| Gene Information | human ... MDM2(4193) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
