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Anti-Phospho-WWTR1-S89 antibody produced in rabbit

品牌
Sigma-Aldrich
货号
SAB5701813
包装型号
规格纯度
参考价格
4266.29 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
Anti-Phospho-WWTR1-S89 antibody produced in rabbit
产品介绍:

产品说明

一般描述

Transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation. Regulates the nuclear accumulation of SMADS and has a key role in coupling them to the transcriptional machinery such as the mediator complex. Regulates embryonic stem-cell self-renewal, promotes cell proliferation and epithelial-mesenchymal transition.

免疫原

A synthetic phosphorylated peptide around S89 of human WWTR1.

外形

Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.

产品性质

生物来源rabbit
质量水平100
antibody product typeprimary antibodies
克隆polyclonal
形式liquid
species reactivityrat, human, mouse
浓度3.06 mg/mL
technique(s)western blot: 1:500-1:2000
UniProt登记号Q9GZV5
运输wet ice
储存温度−20℃
Gene Informationhuman ... WWTR1(25937)

安全信息

闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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