产品说明
一般描述
Polo-like kinases 2 (PLK2) is a member of the serine-threonine kinases family. The PLK2 gene is mapped to human chromosome 5q11.2. PLK2 comprises a C-terminal polo-box domain (PBD) devoid of catalytic activity and an N-terminal kinase domain.
Anti-PLK2 Antibody detects endogenous levels of total PLK2 protein.
免疫原
The antiserum was produced against synthesized peptide derived from human PLK2.
Immunogen Range: 291-340
应用
Anti-PLK2 antibody produced in rabbit has been used in western blotting(1:1000) (1:5000)
生化/生理作用
Polo-like kinase 2 (PLK2) participates in regulating centriole duplication, cell death, and cell cycle. It also mediates the spine-associated RapGAP (SPAR) degradation via the ubiquitin-proteasome pathway, thereby regulating synaptic plasticity. Mutations in the PLK2 gene are observed in colorectal cancers. The PLK2 gene knockdown leads to defects in centriole duplication.
特点和优势
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
外形
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
NACRES | NA.41 |
产品性质
生物来源 | rabbit |
质量水平 | 100 |
偶联物 | unconjugated |
抗体形式 | affinity isolated antibody |
antibody product type | primary antibodies |
克隆 | polyclonal |
形式 | buffered aqueous solution |
分子量 | antigen 78 kDa |
species reactivity | mouse, rat, human |
浓度 | ~1 mg/mL |
technique(s) | ELISA: 1:40000 western blot: 1:500-1:1000 |
NCBI登记号 | Q9NYY3 |
UniProt登记号 | Q9NYY3 |
运输 | wet ice |
储存温度 | −20℃ |
Gene Information | human ... PLK2(10769) |
安全信息
储存分类代码 | 12 - Non Combustible Liquids |
WGK | nwg |
闪点(F) | Not applicable |
闪点(C) | Not applicable |
Sigma-Aldrich