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Anti-PMEL antibody, Mouse monoclonal

品牌
Sigma-Aldrich
货号
SAB4200842
规格纯度
clone PL-19, purified from hybridoma cell culture
参考价格
1794.63 *本价格含增值税费
促销
服务
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数量
-+
产品名称:
Anti-PMEL antibody, Mouse monoclonal
产品介绍:

产品说明

一般描述

The melanocyte-specific protein PMEL (also known as Pmel17, gp100, melanocyte protein, premelanosome protein or silver locus protein homolog (SILV) is a type I transmembrane glycoprotein that is expressed primarily in pigment cells of the eye and skin. In melanosomes, PMEL protein forms a fibrillar matrix on which the UV-shielding pigment melanin is deposited.1-2

特异性

Monoclonal Anti-PMEL antibody specifically recognizes human PMEL protein.

应用

The antibody may be used in various immunochemical techniques including Immunoblotting (~100 kDa), Immunohistochemistry and Immunofluorescence.

生化/生理作用

PMEL fibrils are a major functional component of the melanosomal compartment as they optimize the melanin polymerization, condensation and storage.1,3
In addition, PMEL fibrils have an amyloidogenic nature sharing features with pathological amyloids.4 Thus, PMEL is suggested as an excellent model system to study mechanisms of intracellular amyloid formation.1
Mutations in PMEL are associated with pigmentation disorders and/or impairments in eye development in various species.1,5,6

外形

Supplied as a solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide as a preservative.

储存及稳定性

For continuous use, store at 2-8℃ for up to one month. For extended storage, freeze in working aliquots. Repeated freezing and thawing is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.

免责声明

Unless otherwise stated in our catalog  our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

产品性质

质量水平200
抗体形式purified from hybridoma cell culture
antibody product typeprimary antibodies
克隆PL-19
形式liquid
species reactivityhuman
浓度~1 mg/mL
technique(s)immunoblotting: 1-2 μg/mL using human melanoma SK-MEL-28 cell lysate
immunofluorescence: 1-2 μg/mL using human melanoma SK-MEL-28 cells
同位素/亚型IgG1
UniProt登记号P40967
运输dry ice
储存温度−20℃

安全信息

储存分类代码10 - Combustible liquids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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