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Anti-PPP2R2A antibody produced in rabbit

品牌
Sigma-Aldrich
货号
SAB4300573
规格纯度
affinity isolated antibody
参考价格
5045.46 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
Anti-PPP2R2A antibody produced in rabbit
Anti-FLJ26613 antibody produced in rabbit
Anti-protein phosphatase 2 (formerly 2A), regulatory subunit B, alpha isoform antibody produced in rabbit
Anti-MGC52248 antibody produced in rabbit
Anti-B55-ALPHA antibody produced in rabbit
Anti-B55A antibody produced in rabbit
产品介绍:

产品说明

一般描述

Protein phosphatase 2 regulatory subunit B alpha (PPP2R2A or PP2A/B55) is a heterotrimeric holoenzyme consisting of a scaffolding subunit (A), a regulatory subunit (B) and a catalytic subunit (C). The B subunit, based on the homology is classified into four families, and each has several isoforms. B55 subunit is ubiquitously expressed among all the families of PP2A. In human chromosome, the gene PPP2R2A is localized on 8p21.2.

免疫原

peptide Corresponding to the amino terminal sequence from human PP2A-?protein , according to the protein PPP2R2A.

生化/生理作用

Protein phosphatase 2 regulatory subunit B alpha (PPP2R2A) protein complexes are critical for many cellular processes including cell growth and differentiation, cell motility, DNA damage response, progression of cell cycle and apoptosis. PP2A/B55 dephosphorylates and activates heat shock factor 1 (HSF 1) directly for various cellular processes. Family with sequence similarity 122A (FAM122A) is a endogenous inhibitor of phosphatase activity of PP2A/B55. Overexpression or dysregulation of PP2A has several implications in the developmental stage, embryonic and neonatal death. Polymorphism of PP2A leading to dysregulation is associated with Alzheimer′s disease and various malignancies. Mutations leading to enhanced activity causes asthma, type II diabetes, chronic obstructive lung disorder. Suppression of PPP2R2A expression by micro-RNA892a (mi-R 892a) promotes the growth of colorectal cancer cells. Somatic deletion mutation of PPP2R2A have a potential role in prostate cancer. PPP2R2A functions as a tumour suppressor gene in numerous cancer types. Downregulation of PPP2R2A along with upregulation of cyclin D1 causes aggressiveness in luminal-like breast cancer. PPP2R2A is known to dephosphorylate Tau protein, whose hyperphosphorylation is associated with Alzheimer′s′ disease.

特点和优势

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目标描述

The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.

外形

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

基本信息

NACRESNA.41

产品性质

生物来源rabbit
质量水平100
偶联物unconjugated
抗体形式affinity isolated antibody
antibody product typeprimary antibodies
克隆polyclonal
形式buffered aqueous solution
分子量 ~40 kDa
species reactivityhuman, mouse, rat
浓度1 mg/mL
technique(s)western blot: 1:500-1:1000
同位素/亚型IgG
免疫原序列(S-E-S-Q-V)
NCBI登记号NP_001171062.1
UniProt登记号P63151
运输wet ice
储存温度−20℃
Gene Informationhuman ... PPP2R2A(5520)

安全信息

储存分类代码10 - Combustible liquids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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