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Anti-PRMT8 Antibody

品牌
Sigma-Aldrich
货号
ABS517
规格纯度
from rabbit, purified by affinity chromatography
参考价格
5854.74 *本价格含增值税费
促销
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数量
-+
产品名称:
Anti-PRMT8 Antibody
Protein arginine N-methyltransferase 8, Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 4, Protein arginine methyltransferase 8
产品介绍:

产品说明

一般描述

Asymmetric dimethylation of arginine side chains in proteins is a frequent posttranslational modification, catalyzed by type I protein arginine methyltransferases (PRMTs). PRMT8 is a membrane-associated arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and asymmetrical dimethylarginine (aDMA). PRMT8 can form dimers with PRMT2 or PRMT1 and interacts with FYN kinase. PRMT8 is brain specific and it is a vertebrate restricted paralogue of PRMT1. In the past, arginine methylation was mainly observed on abundant proteins such as RNA-binding proteins and histones, but recent advances have revealed a plethora of arginine-methylated proteins implicated in a variety of cellular processes including signal transduction, epigenetic regulation and DNA repair pathways. PRMT8 has been shown to be critical for proper neuronal development and its expression is regionally restricted in the adult suggesting that PRMT8 is chiefly involved in the somatosensory and limbic systems, and a part of the motor nervous system development and maintenance.

特异性

Other homologies: Homology: predicted to react with rat.

免疫原

Epitope: C-terminal region of SAM-dependent methyltransferase PRMT-type domain
KLH-conjugated linear peptide corresponding to the SAM-dependent methyltransferase PRMT-type domain of Human PRMT8.

应用

This Anti-PRMT8 Antibody is validated for use in Western Blotting and Immunohistochemistry for the detection of PRMT8.
Research Sub Category
Chromatin Biology

Histones
Immunohistochemistry Analysis: A 1:500 dilution from a representative lot detected PRMT8 in human and mouse brain tissuse, and mouse thalamus.
Research Category
Epigenetics & Nuclear Function

Epigenetics & Nuclear Function

质量

Evaluated by Western Blotting using human fetal brain tissue lysate.

Western Blotting Analysis: 0.1 µg/mL of this antibody detected PRMT8 in 10 µg of human fetal brain tissue lysate.

目标描述

~48 kDa observed

外形

Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Antigen Affinity Purified

储存及稳定性

Stable for 1 year at 2-8°C from date of receipt.

其他说明

Concentration: Please refer to lot specific datasheet.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss32160702
NACRESNA.41

产品性质

生物来源rabbit
质量水平100
抗体形式affinity isolated antibody
antibody product typeprimary antibodies
克隆polyclonal
纯化方式affinity chromatography
species reactivitymouse, human
species reactivity (predicted by homology)chicken (based on 100% sequence homology), baboon (based on 100% sequence homology), porcine (based on 100% sequence homology), canine (based on 100% sequence homology), bovine (based on 100% sequence homology)
technique(s)immunohistochemistry: suitable
western blot: suitable
NCBI登记号NP_062828
UniProt登记号Q9NR22
运输wet ice
Gene Informationhuman ... PRMT8(56341)

安全信息

储存分类代码12 - Non Combustible Liquids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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