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Anti-Profilin 1 antibody, Mouse monoclonal

品牌
Sigma-Aldrich
货号
SAB4200357
规格纯度
clone Profilin 1-3, purified from hybridoma cell culture
参考价格
5045.46 *本价格含增值税费
促销
服务
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  • 增值税票
数量
-+
产品名称:
Anti-Profilin 1 antibody, Mouse monoclonal
Anti-PFN1
产品介绍:

产品说明

一般描述

Monoclonal Anti-Profilin 1 (mouse IgG1 isotype) is derived from the hybridoma Profilin1-3 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a synthetic peptide corresponding to a sequence located near the C-terminus of human profiling 1, conjugated to keyhole limpet hemocyanin (KLH). Profilin-1 (Pfn1), a major actin-regulatory protein is mapped to human chromosome17p13. It is the most ubiquitous and abundant protein and is highly expressed throughout development and adulthood in most tissues including brain.

免疫原

synthetic peptide corresponding to a sequence located near the C-terminus of human profilin 1, conjugated to KLH. The corresponding sequence is identical in mouse and rat profilin 1.

应用

Monoclonal Anti-Profilin 1 antibody produced in mouse has been used in immunoblotting and immunoprecipitation.

生化/生理作用

Profilin-1 (Pfn1) is involved in actin polymerization in response to extracellular signals. Profilins were shown to be important for normal cell proliferation, differentiation and motility. Profilin 1 is a potent regulator of actin filament dynamics. It is suggested to act as a tumor suppressor protein based on its reduced expression in several types of invasive cancers and its ability to suppress tumorigenicity when over expressed in breast cancer cells. Deletion of the profilin 1 gene leads to an embryonic lethal phenotype.

外形

0.01M 磷酸缓冲盐溶液,pH 7.4,含 15mM 叠氮化钠。

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

NACRESNA.41

产品性质

质量水平200
生物来源mouse
偶联物unconjugated
抗体形式purified from hybridoma cell culture
antibody product typeprimary antibodies
克隆Profilin 1-3, monoclonal
形式buffered aqueous solution
分子量antigen ~15 kDa
species reactivitycanine, bovine, human, rat, mouse
浓度~1.0 mg/mL
technique(s)immunoprecipitation (IP): suitable
western blot: 1-2 μg/mL using whole extracts of HeLa or NRK cells
同位素/亚型IgG1
UniProt登记号P07737
运输dry ice
储存温度−20℃
Gene Informationhuman ... PFN1(5216)
mouse ... Pfn1(18643)
rat ... Pfn1(64303)

安全信息

储存分类代码12 - Non Combustible Liquids
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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