Anti-PTEN antibody, Rabbit monoclonal

产品说明

一般描述

Phosphatase and tensin homolog deleted on chromosome ten (PTEN), a lipid phosphatase protein, is localized in the cell nucleus. It has a protein tyrosine phosphatase domain. The PTEN gene is located on human chromosome 10q23.

免疫原

Synthetic peptide derived from the C-terminus of human PTEN protein.

生化/生理作用

Phosphatase and tensin homolog deleted on chromosome ten (PTEN) is a tumor suppressor gene. It negatively regulates the phosphatidylinositol 3-kinase (PI3K) pathway. PTEN protein might control the growth of cells through its lipid phosphatase activity. The protein tyrosine phosphatase domain of PTEN is known to dephosphorylate serine, threonine, and tyrosine residues. It may also participate in immune modulation. Mutation in the PTEN gene is associated with rare bilateral choroidal ganglioneuroma. Germline mutations in the PTEN gene are observed in Cowden′s syndrome (CS), Lhermitte–Duclos disease (LDD), and Bannayan–Zonana syndrome (BZS).

特点和优势

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外形

0.1 ml rabbit monoclonal antibody purified by protein A/G in PBS/1% BSA buffer pH 7.6 with less than 0.1% sodium azide.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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