产品说明
一般描述
PXN (paxillin) is a focal adhesion-associated tyrosine-based protein, that is present in the cytoplasm. It is a 68kDa protein that is located on chromosome 12q24.
免疫原
Peptide sequence around aa. 86-90 (P-V-Y-G-S), according to the protein PXN.
应用
Anti-PXN (Ab-88) antibody has been used in immunofluorescence.
生化/生理作用
Paxillin (PXN) controls signal transduction, cell morphology and motility, cytoskeletal rearrangements, proliferation and apoptosis. It serves as an oncogene, hence it plays a major role in the growth of human carcinomas.
特点和优势
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目标描述
Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion).
外形
Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| NACRES | NA.41 |
产品性质
| 生物来源 | rabbit |
| 质量水平 | 100 |
| 偶联物 | unconjugated |
| 抗体形式 | affinity isolated antibody |
| antibody product type | primary antibodies |
| 克隆 | polyclonal |
| 形式 | buffered aqueous solution |
| 分子量 | ~68 kDa |
| species reactivity | human |
| 浓度 | 1 mg/mL |
| technique(s) | indirect immunofluorescence: 1:50-1:100 western blot: 1:500-1:1000 |
| 同位素/亚型 | IgG |
| 免疫原序列 | (P-V-Y-G-S) |
| NCBI登记号 | NP_001074324.1 |
| UniProt登记号 | P49023 |
| 运输 | wet ice |
| 储存温度 | −20℃ |
| Gene Information | human ... PXN(5829) |
安全信息
| 储存分类代码 | 10 - Combustible liquids |
| WGK | WGK 1 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
