Anti-REST antibody produced in rabbit

产品说明

一般描述

REST (RE1 silencing transcription factor) is a transcriptional repressor, which is also termed as NRSF (neuron-restrictive silencer factor).{26,29} It is abundantly present in the body. The gene is located on human chromosome 4q12 (5).

The antibody detects endogenous level of total REST protein.

免疫原

Peptide sequence around aa. 873-877 (R-E-E-A-S), according to the protein NP_001180437.1

生化/生理作用

REST (RE1 silencing transcription factor) plays a major role in hematopoietic and cardiac differentiation. Mutations in REST lead to hereditary gingival fibromatosis. It serves as a tumor suppressor in breast cancer. In human embryonic stem cells, suppression of REST/NRSF affects their survival, lineage differentiation and signaling.

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目标描述

Transcriptional repressor which binds neuron-restrictive silencer element (NRSE) and represses neuronal gene transcription in non-neuronal cells. Restricts the expression of neuronal genes by associating with two distinct corepressors, mSin3 and CoREST, which in turn recruit histone deacetylase to the promoters of REST-regulated genes. Mediates repression by recruiting the BHC complex at RE1/NRSE sites which acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier.

外形

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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