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Anti-RFFL antibody produced in rabbit

品牌
Sigma-Aldrich
货号
HPA017910
规格纯度
Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
参考价格
6389.73 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
Anti-RFFL antibody produced in rabbit
Anti-FYVE-RING finger protein Sakura
Anti-Caspase regulator CARP2
Anti-RING finger and FYVE-like domain-containing protein 1
Anti-CARP-2
Anti-E3 ubiquitin-protein ligase rififylin
Anti-Caspases-8 and -10-associated RING finger protein 2
Anti-Fring
产品介绍:

产品说明

一般描述

Ring finger and FYVE-like domain containing E3 ubiquitin protein ligase (RFFL) contains a zinc finger domain, a pocket for phosphoinositide binding and a loop which helps in membrane insertion. RFFL is localized to endocytic vesicles.

免疫原

E3 ubiquitin-protein ligase rififylin recombinant protein epitope signature tag (PrEST)

应用

All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry.

The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.

生化/生理作用

Ring finger and FYVE-like domain containing E3 ubiquitin protein ligase (RFFL) poly-ubiquitinates and destabilizes proline-rich 5-like (PRR5L). It also targets tumor suppressor p53 for degradation. RFFL functions as a negative regulator of tumor necrosis factor (TNF)-induced NF-κB (NF-κβ) activation by interacting with the internalized TNF-receptor complex.

特点和优势

Prestige Antibodies® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:

  • IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
  • Protein array of 364 human recombinant protein fragments.

联系

Corresponding Antigen APREST74252.

外形

Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide

法律信息

Prestige Antibodies is a registered trademark of sigma-aldrich Co. LLC

基本信息

人类蛋白质图谱编号HPA017910    Human Protein Atlas characterization data

产品性质

生物来源rabbit
质量水平100
偶联物unconjugated
抗体形式affinity isolated antibody
antibody product typeprimary antibodies
克隆polyclonal
产品线Prestige Antibodies® Powered by Atlas Antibodies
形式buffered aqueous glycerol solution
species reactivityhuman
增强验证recombinant expression
Learn more about Antibody Enhanced Validation
technique(s)immunoblotting: 0.04-0.4 μg/mL
immunofluorescence: 0.25-2 μg/mL
immunohistochemistry: 1:20-1:50
免疫原序列AQATSVPPAQVQENQQANGHVSQDQEEPVYLESVARVPAEDETQSIDSEDSFVPGRRASLSDLTDLEDIEGLTVRQLKEILARNF
UniProt登记号Q8WZ73
运输wet ice
储存温度−20℃
Gene Informationhuman ... RFFL(117584)

安全信息

储存分类代码12 - Non Combustible Liquids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable
个人防护装备Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Sigma-Aldrich

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