Anti-RLBP1 Antibody, clone 3C1.1

产品说明

一般描述

Retinaldehyde-binding protein 1 (RLBP1), also known as Cellular retinaldehyde-binding protein, and encoded by the gene RLBP1/CRALBP, is a soluble retinoid carrier protein essential for the proper function of both rod and cone photoreceptors. RLBP1 participates in the regeneration of active 11-cis-retinol and 11-cis-retinaldehyde from the inactive 11-trans products of the rhodopsin photocycle and in the de novo synthesis of these retinoids from 11-trans metabolic precursors. The cycling of retinoids between photoreceptor and adjacent pigment epithelium cells is known as the “visual cycle”. RLBP1 is localized to the cytoplasm. RLBP1 is expressed in retina and pineal gland. It not present in photoreceptor cells but is expressed abundantly in the adjacent retinal pigment epithelium (RPE) and in the Mueller glial cells of the retina. Defects in RLBP1 may be associated with Retinitis pigmentosa, Bothnia retinal dystrophy (BRD), Rod-cone dystrophy Newfoundland, and Retinitis punctata albescens genetic diseases.

免疫原

GST-tagged recombinant protein corresponding to human RLBP1.

应用

Immunohistochemistry Analysis: A 1:2,000 dilution from a representative lot detected RLBP1 in human retina and rat retina tissue.
Research Category
Neuroscience
Research Sub Category
Developmental Signaling
Anti-RLBP1 Antibody, clone 3C1.1 is a highly specific mouse monoclonal antibody, that targets Retinaldehyde-binding protein 1 & has been tested in western blotting & IHC.

质量

Evaluated by Western Blotting in rat eye tissue lysate.

Western Blotting Analysis: 0.5 µg/mL of this antibody detected RLBP1 in 10 µg of rat eye tissue lysate.

目标描述

~37 kDa observed

外形

Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Format: Purified
Protein G Purified

储存及稳定性

Stable for 1 year at 2-8°C from date of receipt.

其他说明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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