Anti-RNF157 antibody produced in rabbit

产品说明

一般描述

RNF157 (ring finger protein 157) is an acidic E3 ubiquitin ligase and is a homolog of E3 ligase MGRN1 (mahogunin ring finger-1). In mice, it shows predominant expression in brain. This gene is localized to human chromosome 17.

免疫原

ring finger protein 157 recombinant protein epitope signature tag (PrEST)

应用

All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry.

The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.

生化/生理作用

RNF157 (ring finger protein 157) controls the survival in culture neurons through its ligase activity. It is also crucial for the growth and maintenance of dendrites. It also interacts with and degrades APBB1 (amyloid β precursor protein-binding, family B, member 1), which is key in the control of survival of neurons. Its sequence similarity to LOG2 (LOSS OF GDU 2) and MGRN1 (mahogunin ring finger-1) suggests that this protein might play a role in the control of membrane protein trafficking.

特点和优势

Prestige Antibodies^® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies^® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:

• IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
• Protein array of 364 human recombinant protein fragments.

联系

Corresponding Antigen APREST75680.

外形

Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide.

法律信息

Prestige Antibodies is a registered trademark of sigma-aldrich Co. LLC

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