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ANTI-RUNX1 antibody produced in mouse

品牌
Sigma-Aldrich
货号
SAB1412470
规格纯度
clone 3A8, purified immunoglobulin, buffered aqueous solution
参考价格
5045.46 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
ANTI-RUNX1 antibody produced in mouse
AML1
RUNX1
CBFA2
AML1-EVI-1
AMLCR1
产品介绍:

产品说明

一般描述

Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. The protein encoded by this gene represents the alpha subunit of CBF and is thought to be involved in the development of normal hematopoiesis. Chromosomal translocations involving this gene are well-documented and have been associated with several types of leukemia. Three transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq)

免疫原

RUNX1 (NP_001001890.1, 210 a.a. ~ 310 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Sequence
RVSPHHPAPTPNPRASLNHSTAFNPQPQSQMQDTRQIQPSPPWSYDQSYQYLGSIASPSVHPATPISPGRASGMTTLSAELSSRLSTAPDLTAFSDPRQFP

生化/生理作用

RUNX1 plays a vital role in tumour suppression and oncogenic activities. In hematopoiesis, it is involved in hematopoietic development, hematopoietic stem cell homeostasis, and various blood malignancies. It may have clinicopathological impact on the proliferation of human bone marrow cells used in transplantation therapy.

外形

Solution in phosphate buffered saline, pH 7.4

基本信息

NACRESNA.41

产品性质

质量水平100
生物来源mouse
偶联物unconjugated
抗体形式purified immunoglobulin
antibody product typeprimary antibodies
克隆3A8, monoclonal
形式buffered aqueous solution
分子量antigen 36.85 kDa
species reactivityhuman
technique(s)immunohistochemistry: suitable
indirect ELISA: suitable
indirect immunofluorescence: suitable
同位素/亚型IgG2bκ
NCBI登记号NM_001001890
UniProt登记号Q01196
运输dry ice
储存温度−20℃
Gene Informationhuman ... RUNX1(861)

安全信息

储存分类代码12 - Non Combustible Liquids
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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