您好,欢迎来到试剂仪器网! [登录] [免费注册]
试剂仪器网
位置:首页 > 品牌 > Sigma-Aldrich > Anti-SATB1 antibody, Mouse monoclonal

Anti-SATB1 antibody, Mouse monoclonal

品牌
Sigma-Aldrich
货号
SAB4200481
规格纯度
clone SAT-5, purified from hybridoma cell culture
参考价格
5001.78 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
Anti-SATB1 antibody, Mouse monoclonal
Anti-Special AT-rich sequence-binding protein 1
Anti-SATB homeobox 1
Monoclonal Anti-SATB1 antibody produced in mouse
产品介绍:

产品说明

一般描述

Monoclonal Anti-SATB1 (mouse IgG2a isotype) is derived from the hybridoma SAT-5 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a synthetic peptide corresponding to a sequence at the N-terminus of human special AT-rich sequence-binding protein 1 (SATB1), conjugated to keyhole limpet hemocyanin (KLH). SATB1 encodes as nuclear matrix protein that interacts with scaffold-associating DNA. SATB1 gene is mapped to human chromosome 3p24.3.

免疫原

a synthetic peptide corresponding to a sequence at the N-terminus of human SATB1, conjugated to KLH.

应用

Monoclonal Anti-SATB1 antibody produced in mouse has been used in:

  • immunoblotting
  • immunocytochemistry
  • flow cytometry

生化/生理作用

Special AT-rich sequence-binding protein 1 (SATB1) is a tumor promotor gene that plays an important role in regulating gene expression. The SATB1 known to be involved in organizing higher-order chromatin structure including the subnuclear organization of individual genes within multigene clusters in a tissue specific manner, locally and at a distance. It controls the global chromatin architecture via promyelocytic leukemia protein (PML). SATB1 also regulates the periodic anchoring of matrix attachment regions (MARs) in DNA to the nuclear matrix. This organizes chromatin into distinct loops. Furthermore, SATB1 recruits co-repressor complexes to its binding sites. SATB1 is abnormally expressed in human metastatic breast cancer and also promotes breast cancer tumor growth and metastasis. It is involved in the tumorigenesis of colorectal, coetaneous malignant melanoma and lung cancers. SATB1 also serves as a possible prognostic marker.

外形

0.01M 磷酸缓冲盐溶液,pH 7.4,含 15mM 叠氮化钠。

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

NACRESNA.41

产品性质

质量水平200
生物来源mouse
偶联物unconjugated
抗体形式purified from hybridoma cell culture
antibody product typeprimary antibodies
克隆SAT-5, monoclonal
形式buffered aqueous solution
分子量antigen ~100 kDa
species reactivityhuman, mouse, rat, monkey
浓度~1.0 mg/mL
technique(s)flow cytometry: 5-10 μg using THP-1 cells
immunocytochemistry: suitable
western blot: 2.0-4.0 μg/mL using Jurkat total cell extracts
UniProt登记号Q01826
运输dry ice
储存温度−20℃
Gene Informationhuman ... SATB1(6304)

安全信息

储存分类代码12 - Non Combustible Liquids
WGKWGK 2
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

推荐产品