Anti-Scribble Antibody

产品说明

一般描述

Scribble is a tumor suppressor marker first discovered in Drosophila that has been implicated in the control of cell proliferation, polarity, invasion, and metastasis (Humbert, et al, 2003). Mammalian Scribble expresses basolateral staining in epithelial tissue and highly polarized expression in T lymphocytes (Dow, et al, 2003) (Ludford-Menting, et al, 2005), and plays an essential role in the regulation of the polarity specifically involved in directed epithelial migration. Altered expression of human Scribble is associated with invasive epithelial cancers, however, its role in tumour development remains unclear (Dow, et al, 2007).

特异性

Predicted to cross react with mouse based on sequence homology. Reactivity with other species has not been tested.

免疫原

GST-tagged fusion protein corresponding to the PDZ2 domain of Scribble
Epitope: PDZ2 domain of Scribble

应用

Research Sub Category
Tumor Markers

Cytoskeleton
This Anti-Scribble Antibody is validated for use in WB for the detection of Scribble.
Suggested dilutions:
Western blot: 0.2 µg (1:2000)

质量

Routinely evaluated by Western blot on HeLa cell lysates.

目标描述

220 kDa

外形

Protein G Chromatography
Purified in PBS containing with 0.05% NaN3.
Format: Purified

储存及稳定性

Maintain at 2-8°C for up to 1 year after date of receipt.

其他说明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

法律信息

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
GenBank is a registered trademark of United States Department of Health and Human Services

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

产品性质

安全信息