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Anti-SDC3

品牌
Sigma-Aldrich
货号
SAB4301620
规格纯度
affinity isolated antibody
参考价格
5097.31 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
Anti-SDC3
SYND3
SDCN
产品介绍:

产品说明

一般描述

Syndecan 3 (SDC3) also known as neuronal syndecan (N-syndecan), belongs to the transmembrane heparan sulphate proteoglycan family. It is expressed predominantly in brain, and also in ovary, uterus, cartilage, skeletal muscle and pancreatic cells. In human chromosome, the gene SDC3 is localized on 1p35.2.

免疫原

Synthetic peptide corresponding to residues near the C terminal of human syndecan 3

应用

Anti-SDC3 has been used in western blot analysis and immunohistochemistry studies.

生化/生理作用

Syndecan 3 (SDC3) maintains cell shape and transfers signals from the cell surface to actin cytoskeleton. It depends on carbohydrate for the process. SDC3 is a potential modulator of gonadal steroid hormone function. SDC3 is a co-receptor for growth factors and extracellular matrix components like basic fibroblast growth factor, heparin binding growth-associated molecule, epidermal growth factor receptor and notch signalling ligands. Thus, SDC3 is involved in various functions like cell adhesion, cell-cell interaction and regulation of ligand-receptor binding. In brain, SDC3 regulates neurite outgrowth and neuronal migration. SDC3 is involved in formation of synapses to maintain homeostasis of feeding behaviour and body weight. SDC3 is one of the potential marker for obesity. Polymorphism is SDC3 leads to obesity and in female obesity is linked with hyperandrogenism. SDC3 binds with tissue factor pathway inhibitor (TFPI) in the cell surface of cancer cells. High expression of SDC3 and Pleiotrophin is involved in metastasis and tumor progression in pancreatic cancer. SDC3 expression is regulated by microRNA (miR-144-5p) (passenger strand) and leads to cancer cell aggressiveness in renal cancer.

特点和优势

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

外形

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

基本信息

NACRESNA.41

产品性质

生物来源rabbit
质量水平100
抗体形式affinity isolated antibody
antibody product typeprimary antibodies
克隆polyclonal
形式buffered aqueous glycerol solution
species reactivitymouse, rat, human
technique(s)immunohistochemistry: 1:25-1:100
western blot: 1:200-1:1000
登记号NP_055469
UniProt登记号O75056
运输wet ice
储存温度−20℃
Gene Informationhuman ... SDC3(9672)

安全信息

储存分类代码12 - Non Combustible Liquids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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