产品说明
一般描述
SIRT5 (Sirtuin 5) is a mitochondrial matrix protein belonging to the class III of the sirtuin family. It is localized inside the mitochondria and within the cytosol and nucleus. The protein is widely expressed in the brain, heart, liver and kidney. It is composed of very short amino and carboxyl terminal sequences flanking region with the conserved, catalytic sirtuin center domain.
免疫原
SIRT5 antibody was raised against a 17 amino acid peptide near the carboxy terminus of human SIRT5.
应用
Anti-SIRT5 antibody produced in chicken is suitable for western blot and indirect ELISA.
生化/生理作用
SIRT5 (Sirtuin 5) is associated with metabolism and aging process. It has been reported in a study that SIRT5 influences urea cycle pathway by NAD-dependent deacetylation and subsequent activation of carbamoyl phosphate synthetase 1 (CPS1), which plays a vital role in the initial step of urea cycle for the detoxification and removal of ammonia. In non-small cell-lung cancer cells. SIRT5 contributions have also been observed for the cancer cell growth and drug resistance. Study shows that SIRT5 may possess oncogenic property.
特点和优势
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
联系
The action of this antibody can be blocked using blocking peptide SBP3500496.
外形
Supplied in PBS with 0.02% sodium azide.
基本信息
| NACRES | NA.41 |
产品性质
| 生物来源 | chicken |
| 质量水平 | 100 |
| 偶联物 | unconjugated |
| 抗体形式 | affinity isolated antibody |
| antibody product type | primary antibodies |
| 克隆 | polyclonal |
| 形式 | buffered aqueous solution |
| species reactivity | human, mouse |
| technique(s) | indirect ELISA: suitable western blot: suitable |
| NCBI登记号 | NP_036373 |
| UniProt登记号 | Q9NXA8 |
| 运输 | dry ice |
| 储存温度 | −20℃ |
| Gene Information | human ... SIRT5(23408) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
