产品说明
一般描述
Spermine oxidase (SMOX) gene mapped to human chromosome 20p13, is a flavin adenine dinucleotide (FAD)-dependent oxidase. It encodes nucleus and cytoplasmic specific splice variants.
免疫原
synthetic peptide corresponding to amino acids 151-165 of human SMOX
应用
Anti-SMOX (151-165) antibody produced in rabbit has been used in western blotting.
生化/生理作用
Spermine oxidase (SMOX) catabolizes spermine to spermidine, 3-aminopropanal and hydrogen peroxide. This catalytic activity of SMOX leads to apoptosis and DNA damage in gastric epithelial cells. It is highly expressed in H. pylori infected gastritis tissues and in ulcerative colitis (UC). Induced SMOX expression in breast cancer using spermine analogs is regarded as an effective anticancer treatment regime. It is regarded as a key marker correlating chronic inflammation with epithelial carcinogenesis. Elevation in the SMO levels is observed in inflammatory bowel disease and is implicated in the immunopathogenesis of Citrobacter rodentium infection mediated colitis.
外形
0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| NACRES | NA.41 |
产品性质
| 生物来源 | rabbit |
| 偶联物 | unconjugated |
| 抗体形式 | IgG fraction of antiserum |
| antibody product type | primary antibodies |
| 克隆 | polyclonal |
| 形式 | buffered aqueous solution |
| 分子量 | ~56 kDa |
| species reactivity | human |
| technique(s) | western blot: 1:500-1:2,000 |
| UniProt登记号 | Q9NWM0 |
| 运输 | dry ice |
| 储存温度 | −20℃ |
| Gene Information | human ... SMOX(54498) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | nwg |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
