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Anti-sTRAIL Antibody, clone III6F

品牌
Sigma-Aldrich
货号
MABF118
规格纯度
clone III6F, from mouse
参考价格
3957.76 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
Anti-sTRAIL Antibody, clone III6F
Tumor necrosis factor ligand superfamily member 10, Apo-2 ligand, Apo-2L, TNF-related apoptosis-inducing ligand, Protein TRAIL, CD253
产品介绍:

产品说明

一般描述

TNF-related apoptosis-inducing ligand (sTRAIL or Apo-2L) is the endogenous ligand for the ubiquitous pro-apoptotic TRAIL-R1 and TRAIL-R2 receptors. Upon ligand binding, TRAIL receptors form trimeric structures at the plasma membrane around a central zinc atom. The trimeric TRAIL receptors bind the FADD adaptor protein which in turn recruits caspase 8. TRAIL/APO-2L signals ultimately converge on caspase 3 and related proteins that promote cell death. Importantly, activated TRAIL receptors work cooperatively with death receptors 4 and 5 in transformed cells to induce caspase signaling, thereby preventing the proliferation of abnormal cells. TRAIL/ApO-2L has been implicated in pathophysiology of many disease processes, including cancer and autoimmune diseases.

免疫原

Human soluble TRAIL

应用

Research Sub Category
Apoptosis - Additional
Immunohistochemistry Analysis: A representative lot from an independent laboratory detected sTRAIL in frozen sections from human tonsils, lymph nodes and appendix (Liabakk, N. B., et al. (2002). J Immunol Methods. 259(1-2):119-128.).

Flow Cytometry Analysis: A representative lot from an independent laboratory detected sTRAIL in REH cells (Liabakk, N. B., et al. (2002). J Immunol Methods. 259(1-2):119-128.).
Research Category
Inflammation & Immunology
This Anti-sTRAIL Antibody, clone III6F is validated for use in Flow Cytometry, IHC, Immunoprecipitation for the detection of sTRAIL.

质量

Evaluated by Flow Cytometry in HeLa cells.

Flow Cytometry Analysis: 2.5 µg/mL of this antibody detected sTRAIL in 2X10E5 HeLa cells.

目标描述

33 kDa calculated

外形

Purified mouse monoclonal IgG2bκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Format: Purified
Protein G Purified

储存及稳定性

Stable for 1 year at 2-8°C from date of receipt.

分析说明

Control
HeLa cells

其他说明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss32160702
NACRESNA.41

产品性质

质量水平100
生物来源mouse
抗体形式purified immunoglobulin
antibody product typeprimary antibodies
克隆III6F, monoclonal
species reactivityhuman
technique(s)flow cytometry: suitable
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
同位素/亚型IgG2bκ
NCBI登记号NP_003801
UniProt登记号P50591
运输wet ice
Gene Informationhuman ... TNFSF10(8743)

安全信息

储存分类代码12 - Non Combustible Liquids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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