Anti-STUB1 antibody produced in rabbit

产品说明

一般描述

STUB1 (STIP1 homology and U-box containing protein 1) codes for CHIP (C-terminus of HSC70-interacting protein). It is located on human chromosome 16p13.3.

免疫原

Synthetic peptide directed towards the C terminal region of human STUB1

生化/生理作用

STUB1 modulates the activity of several chaperone complexes, including Hsp70, Hsc70 and Hsp90. It has E3 ubiquitin-protein ligase activity and targets misfolded chaperone substrates towards proteasomal degradation. STUB1 mediates the transfer of non-canonical short ubiquitin chains to HSPA8 that have no effect on HSPA8 degradation.
Mutations in STUB1 (STIP1 homology and U-box containing protein 1) result in autosomal recessive cerebellar ataxia (ARCA). The carboxyl terminus of the Hsc70?interacting protein (CHIP) has the ability to stimulate ubiquitination and degradation of various oncogenic proteins. It also plays a vital role in blocking tumor progression and invasion.

序列

Synthetic peptide located within the following region: VDEKRKKRDIPDYLCGKISFELMREPCITPSGITYDRKDIEEHLQRVGHF

外形

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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