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Anti-Syntaphilin Antibody

品牌
Sigma-Aldrich
货号
ABN647
规格纯度
from rabbit, purified by affinity chromatography
参考价格
5854.74 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
Anti-Syntaphilin Antibody
Syntaphilin
产品介绍:

产品说明

一般描述

Syntaphilin (SNPH) is a single-pass membrane protein that was initially identified in a yeast two-hybrid screen with the carboxy terminal region of Syntaxin-1 as bait. Syntaxin-1 is a key component of the synaptic vesicle docking machinery that forms the SNARE complex with synaptobrevin and SNAP-25. Syntaphilin competes with SNAP-25 for binding to syntaxin-1 and inhibits the formation of the SNARE complex, thereby potentially regulating synaptic vesicle exocytosis. Syntaphilin also binds dynamin-1 and inhibits dynamin-dependent endocytosis. Mice lacking syntaphilin show an increased level of mitochondrial motility and a reduced density of axonal mitochondria. This correlates with an enhanced short-term facilitation and significant impairments in motor ability, suggesting syntaphilin plays a major role in presynaptic function.

免疫原

Epitope: center region
KLH-conjugated synthetic peptide corresponding to the center region of human Syntaphilin.

应用

Research Category
Neuroscience
Research Sub Category
Developmental Neuroscience
Immunohistochemistry Analysis: 5 μg/mL from a representative lot detected Syntaphilin in human brain tissue.

Immunofluorescence Analysis: 20 μg/mL from a representative lot detected Syntaphilin in human brain cells.
Anti-Syntaphilin Antibody is an antibody against Syntaphilin for use in western blotting, IHC & immunofluorescence.

质量

Evaluated by Western Blotting in rat brain tissue lysate.

Western Blotting Analysis: 2 μg/mL of this antibody detected Syntaphilin in rat brain tissue lysate.

目标描述

~86 kDa observed. Uncharacterized bands may be observed in some lysate(s). Despite its predicted molecular weight, Syntaphilin usually migrates at higher molecular weight in SDS-PAGE.

外形

Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.
Antigen Affinity Purified

储存及稳定性

Stable for 1 year at 2-8°C from date of receipt.

其他说明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss32160702
NACRESNA.41

产品性质

生物来源rabbit
质量水平100
抗体形式affinity isolated antibody
antibody product typeprimary antibodies
克隆polyclonal
纯化方式affinity chromatography
species reactivityhuman
technique(s)immunofluorescence: suitable
immunohistochemistry: suitable
western blot: suitable
UniProt登记号O15079
运输wet ice
Gene Informationhuman ... SNPH(9751)

安全信息

储存分类代码10 - Combustible liquids
WGKWGK 2
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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