Anti-TES antibody ,Mouse monoclonal

产品说明

一般描述

Monoclonal Anti-TES (mouse IgG3 isotype) is derived from the hybridoma TES75 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a synthetic peptide. Testin LIM domain protein (TES) comprises cysteine-rich zinc-binding motifs called LIM domains and is a component of focal adhesions. TES gene is mapped to a common fragile site on chromosome 7q31.2 is designated as FRA7G.

特异性

Monoclonal Anti-TES recognizes human, monkey, bovine, and mouse TES

应用

Anti-TES antibody, mouse monoclonal may be used in immunoblotting.

生化/生理作用

Testin LIM domain protein (TES), a putative tumor-suppressor gene, is essential for motility and is key for the tumor cell anchorage and metastasis. TES mRNA expression is found in several cancer-derived cell lines, particularly hematopoietic, breast and ovarian cancer cell lines as well as in primary tumors. This was correlated with methylation of TES CpG island. Furthermore, TES gene knockout revealed its role as a tumor suppressor gene as well as in actin stress fibre organization.

外形

0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。

储存及稳定性

Store at –20 ℃. For continuous use, the product may be stored at 2–8 ℃ for up to one month. For extended storage, freeze at –20 ℃ in working aliquots. Repeated freezing and thawing, or storage in “frost-free” freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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