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Anti-TFE3 antibody produced in rabbit

品牌
Sigma-Aldrich
货号
SAB4200803
规格纯度
affinity isolated antibody, buffered aqueous solution
参考价格
2367.82 *本价格含增值税费
促销
服务
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数量
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产品名称:
Anti-TFE3 antibody produced in rabbit
Anti-Class E basic helix-loop-helix protein 33
Anti-bHLHe33
Anti-Transcription factor E3
产品介绍:

产品说明

一般描述

Transcription factor E3 (TFE3), also known as Class E basic helix-loop-helix protein 33 (bHLHe33), is a transcriptional activator that mediates the enhancer-promoter interactions. TFE3 belongs to the MiT family of helix-loop-helix leucine zipper transcription factors, it is ubiquitously expressed and can directly associate with DNA as either homodimer or heterodimer formed with two other MiT family members, TFEB or TFEC. TFE3 serves an important role in cell growth, cell proliferation, in cellular adaptation to starvation and cellular response to ER stress. Under nutrient-rich conditions TFE3 is located in the cytoplasm, under starvation conditions or treatment with ER stressors, TFE3 rapidly translocated to nuclear, there it mediates cellular adaptation to stress by simultaneously promoting lysosomal biogenesis, autophagy induction, as well as expression of critical mitochondrial and metabolic regulators. TFE3 has been shown to participate in the transcriptional regulation of the innate immune response. in addition, it was demonstrated that pathogen infections promote TFE3 nuclear translocation, thus inducing the expression of several cytokines and chemokines.

Anti-TFE3 antibody specifically recognizes TFE3 from human and mouse origin.

免疫原

Synthetic peptide corresponding to the human TFE3

应用

The antibody may be used in various immunochemical techniques including Immunoblotting (∼60 kDa) and Immunofluorescence. Detection of the TFE3 band by Immunoblotting is specifically inhibited by the immunizing peptide.

外形

Supplied as a solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide as a preservative.

其他说明

This product is for R&D use only, not for drug, household, or other uses.

基本信息

NACRESNA.41

产品性质

生物来源rabbit
抗体形式affinity isolated antibody
antibody product typeprimary antibodies
克隆polyclonal
形式buffered aqueous solution
分子量 ~60 kDa
species reactivityhuman, mouse
包装antibody small pack of 25 μL
浓度~1.0 mg/mL
technique(s)immunoblotting: 4-8 μg/mL using human HeLa cells extract
immunofluorescence: 2.5-5 μg/mL using mouse embryo fibroblast NIH-3T3 cells
UniProt登记号P19532
运输dry ice
储存温度−20℃
Gene Informationhuman ... TFE3(7030)

安全信息

储存分类代码12 - Non Combustible Liquids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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